Phoenix - Spring 2023

What is mathematical oncology?

The integration and application of mathematical and computational models to better understand and predict cancer initiation, progression and treatment.

What is the purpose of this conference?

To support the growing momentum in our field of Mathematical Oncology, we feel the time is ripe to establish a new regularly recurring (annual or bi-annual) meeting that will provide an international venue for collaboration, integration, training and synergy for our exciting fusion of disciplines. A major focus of this conference will be Sex Differences in Cancer, in part due to the research focus of Kristin Swanson (local host and chair) and generous support from the McDonnel Foundation.

Where will the conference be held?

The conference will be held at the DoubleTree Resort by Hilton Hotel Paradise Valley hotel, Phoenix, AZ

Who are the conference co-chairs?

Kristin Swanson (Mayo Clinic) and Sandy Anderson (Moffitt).

When will the conference be held?

30th April - 3rd May.


We are excited to announce the inaugural Mathematical Oncology meeting in Spring 2023 (30th April - 3rd May) in Phoenix. This international meeting builds on the robust legacy of growing initiatives related to the application of mathematical and computational approaches in cancer biology and clinical oncology including:

To support the growing momentum in our field of Mathematical Oncology, we feel the time is ripe to establish a new regularly recurring (annual or bi-annual) meeting that will provide an international venue for collaboration, integration, training and synergy for our exciting fusion of disciplines. We look forward to seeing you in Phoenix to launch the next chapter in Mathematical Oncology as we leverage the power of mathematics to drive forward positive change for patients with cancer.


Kristin & Sandy

Meeting Co-Chairs

Abstract submission has closed. Please register for the conference here:

Conference Registration

If you wish to not attend onsite but rather livestream the conference for a discounted rate, during registration please use COUPON CODE: MATHONC23-LIVESTREAM.

The conference will be held on location at the DoubleTree Resort by Hilton Hotel Paradise Valley hotel (5401 N. Scottsdale Rd. Scottsdale, AZ 85250). There is a Group Code for a conference rate "CDTMYO", available until until April 24th. More options for lodging and accommodations are found below.

Lodging & Accommodations


Structure of the meeting

The meeting will be a mix of didactic and abstract sessions. Didactic sessions seek to provide overviews to allow clinicians to engage the mathematics and for the modelers to engage the holy grail challenges in oncology. The abstract sessions will provide candidate solutions related to those challenges. Each abstract session will be pre-ambled by a tutorial/didactic session providing a foundation in the area. Example (but not inclusive) themes of didactic sessions include: Intro to Mathematical Oncology, Sex differences in Cancer, Intro to Immunotherapy, Intro to Biomarkers, Intro to Evolutionary Therapy, Intro to Tumor-Stromal Interactions, Intro to Genomics and Intracellular Dynamics.

Optional Hike Ideas

There are numerous areas to hike near the hotel, including a few trail heads of increasing difficulty. Be sure to bring lots of water and turn back when water is at 50%! Uber to trailheads or coordinate with local folks!

Session 0: Sunday, April 30th

Time Agenda Item
5:00pm Pickup at conference hotel for transport to the poster session to be held at Mayo Clinic
5:30-7:30pm Poster session will be held at the Swanson lab

The conference begins on Sunday, April 30th with a poster session and reception.

Poster session and reception is held at: 5711 East Mayo Blvd, Support Services Building (SSB) Suite 2-700, Phoenix AZ 85054 (see map). For those choosing to arrive separately, parking is available directly in the front (north side) or on the west side of the Support Services Building.

(Click to expand)

Conference shuttles will provide transportation to the Mayo Clinic poster session and reception departing the front lobby of the conference hotel at 5pm on Sunday April 30th.

Session 1: Monday, May 1st

Time Agenda Item
7:45-8:30am Breakfast
8:30-8:45am Welcome & announcements
8:45-9:45am Plenary 1: Jacob Scott
Fitness landscapes, clonal selection, cell-cell interactions, Part 1
9:45-10:00am David Basanta: An integrated game theoretical model describing tumor evolutionary dynamics under environmentally mediated protection
10:00-10:15am Svyatoslav Tkachenko: How do public-good producing clones invade a tumor population?
10:15-10:30am Zachary Compton: The Logic of Evolution Traps in Estrogen Receptor Negative Breast Cancers
10:30-11:00am Break
11:00-11:45am Didactic 1: Melissa Wilson, "Sex chromosomes"
Fitness landscapes, clonal selection, cell-cell interactions, Part 2
11:45am-noon Rowan Barker-Clarke: De-coupling cell-intrinsic and cell-extrinsic effects to model and interpret drug-dependent evolutionary games
noon-12:15pm Jill Gallaher: Selection of evolvability as a trait in cancer growth and treatment
12:15-12:30pm Malgorzata Tyczynska Weh: Modeling selection for evolvability in the evolution of cancer therapy resistance
12:30-1:30pm Break
1:30-2:15pm Didactic 2: Bob Gatenby, "Evolutionary therapy"
Evolutionary Dynamics, Part 1
2:15-2:30pm Diego Mallo Adan: Tick Tock Trees: Reconstructing the evolutionary dynamics of human tissues using fluctuating methylation clocks
2:30-2:45pm Ryan Schenck: The polyclonal path towards malignant transformation in familial adenomatous polyposis
2:45-3:00pm George Butler: Punctual evolution is pervasive in metastatic dissemination
3:00-3:30pm Break
Evolutionary / adaptive therapy
3:30-3:45pm Daniel Saha: Simulation studies suggest which cancers are best suited for adaptive therapy
3:45-4:00pm Carlo Maley: Simulation Studies to Improve Adaptive Therapy
4:00-4:15pm Kit Gallagher: Learning to Adapt - Deep Reinforcement Learning in Treatment-Resistant Prostate Cancer
4:15-4:30pm Mark Robertson-Tessi: Implementing evolutionary therapy strategies for individual patients in real time: interim results from the Evolutionary Tumor Board pilot trial
4:30-4:45pm Maximilian Strobl: Adaptive therapy for ovarian cancer: An integrated approach to PARP inhibitor scheduling
4:45-5:00pm Rafael Ramon Bravo: Investigating the impact of normal tissue density on the effectiveness of Adaptive Therapy in an imaging-scale model
5:30pm Sunset Hike (optional)
7:30-9:30pm Conference dinner at the mission

Session 2: Tuesday, May 2nd

Time Agenda Item
7:45-8:30am Breakfast
8:30-8:45am Welcome & announcements
8:45-9:45am Plenary 2: Dominik Wodarz
Evolutionary Dynamics, Part 2
9:45-10:00am Magnus Haughey: On the use of spatial genomic data to reconstruct somatic evolutionary dynamics
10:00-10:15am Konstantinos Mamis: A simple stochastic model for cell population dynamics in colonic crypts
10:15-10:30am Jona Kayser: Resistance Evolution in Compact Populations
10:30-11:00am Break
11:00-11:45am Didactic 3: Josh Rubin, "Sex differences in cancer"
Tumor growth dynamics
11:45am-noon Christopher McFarland: Quantifying the cell-intrinsic and cell-extrinsic growth effects of cancer-causing mutations in vivo
noon-12:15pm Andrea Hawkins-Daarud: Dynamics of immune cells predicted from imaging connect to survival after dendritic vaccine therapy
12:15-12:30pm Stefano Pasetto: Calibrating tumor growth and invasion parameters with spectral-spatial analysis of cancer biopsy tissues
12:30-1:30pm Break
1:30-2:15pm Didactic 4: Andriy Marusyk, "Tumor-stromal interactions"
Treatment response & resistance
2:15-2:30pm Jeffrey West: Applying the principles of convexity and concavity to guide treatment scheduling of ALK inhibitors in non-small cell lung cancer
2:30-2:45pm Adam Palmer: Accurate prediction of the clinical efficacy of combinations of cancer therapies
2:45-3:00pm Vural Tagal: Ploidy as a predictive biomarker for gemcitabine sensitivity in triple-negative breast cancers
3:00-3:30pm Break
Tumor-immune dynamics
3:30-3:45pm Elizabeth Borden: NeoScore Integrates Characteristics of the Neoantigen:MHC Class I Interaction and Expression to Accurately Prioritize Immunogenic Neoantigens
3:45-4:00pm Ernesto A.B.F. Lima: Investigating the effect of hypoxia on immunotherapy response in murine models of colon cancer using mathematical modeling
4:00-4:15pm Kayode Olumoyin: ML-PETIL: A Machine Learning Predictor of the Expansion of Tumor Infiltrating Lymphocytes in Patients’ Bladder Tumors
4:15-4:30pm Nat Kendal-Freedman: Modelling the Role of T-Regulatory Cells on Relapse Following Car T-Cell Therapy
4:30-4:45pm Parag Katira: GBM communities: exploiting the interactions between ploidy and host physiology
4:45-5:00pm Patrick Gelbach: Ensemble-based Genome-scale Modeling Predicts Metabolic Differences between Macrophage Subtypes in Colorectal Cancer
5:30pm Sunset hike (optional)
6:30pm Dinner on your own

Session 3: Wednesday, May 3rd

Time Agenda Item
7:45-8:30am Breakfast
8:30-8:45am Welcome & announcements
8:45-9:45am Plenary 3: Ivana Bozic
Spatio-temporal models, Part 1
9:45-10:00am Lee Curtin: Image-localized Biopsy Mapping of Brain Tumor Heterogeneity: A Single-Center Study Protocol
10:00-10:15am Nikolaos Dimitriou: Investigating sedimentation in 3D cultures with an integrated experimental-computational framework
10:15-10:30am Pamela Jackson: Image-based modeling map of edema is correlated with multiple blood-brain-barrier permeability markers in brain tumor patients
10:30-11:00am Break
11:00-11:45am Didactic 5: Kristin Swanson, "Sex differences in MathOnc"
Spatio-temporal models, Part 2
11:45am-noon Pedro Lowenstein: Spatio-temporal organization of brain tumors: from oncostreams to liquid crystals
noon-12:15pm Sebastien Motsch: Self-organization in malignant brain tumors: emergence of oncostreams
12:15-12:30pm Tatiana Miti: Using ABMs to Study Stromal Effects on the Remission-Relapse Dynamics of NSCLC and TNBC
12:30-1:30pm Break
1:30-2:15pm Didactic 6: Sandy Anderson, "Agent-based models"
Predictive modeling & parameter estimation
2:15-2:30pm Colin Cess: Representation learning for tumor agent-based model parameter estimation
2:30-2:45pm Hugo Miniere: A mathematical model for predicting the spatio-temporal response of breast cancer cells treated with doxorubicin
2:45-3:00pm Reshmi Patel: Predicting the response of I-SPY 2 breast cancer patients to treatment using a mechanism-based model and quantitative MRI data
3:00-3:30pm Break
Plasticity, epigenetics, & evolvability
3:30-3:45pm Einar Bjarki Gunnarsson: Estimation of the rates of cell proliferation and phenotypic switching in cancer and implications for treatment
3:45-4:00pm Erin Angelini: A model for the intrinsic limit of cancer therapy: Duality of treatment-induced cell death and treatment-induced stemness
4:00-5:30pm Panel: Future of MathOnc
5:30pm Dinner on your own


Funding for the meeting generously provided by:

NCI PSOC and CSBC programs, the J. S. McDonnell foundation (, as well as the Mayo Clinic Comprehensive Cancer Center.

Please join us!

Kristin Swanson

Kristin Swanson
Mayo Clinic
Conference Chair
Sandy Anderson

Sandy Anderson
Moffitt Cancer Center
Conference Co-Chair