Group Leader: MacLean Lab @ University of Southern California
Los Angeles, California, USAKeywords (click a keyword to view other similar labs): theoretical • cell fate decision-making • single-cell biology • dynamical systems • gene regulatory networks • statistical inference • EMT • breast cancer • hematopoiesis.
Description: We use theoretical approaches to gain insight into cell fate decision-making in vivo. We study development and cancer, from the perspective of adult stem cell fate decisions, and how these go awry. We develop new mathematical models and computational tools rooted in dynamical systems theory, statistical inference, and machine learning to discover new biology, in light of the wealth of information we can gain by analyzing high-dimensional, single-cell datasets.