Mathematical Oncology

Jason T. George

Group Leader: George research group @ Texas A&M University

Houston, Texas, USA

Description: Our research group is focused on developing and applying mathematical and statistical models to explain and predict the behavior of complex biological systems, with a particular focus on cancer and T cell immunology. Our foundational modeling efforts utilize mathematical analysis, probability and stochastic process theory, and statistical mechanics to describe dynamic biological processes. Applied work is directed at the development of computational tools for the interpretation of biological phenotypes implicated in health and human disease. We have applied this approach to understand cancer evolution and immune escape, the recognition capacity of an adaptive immune repertoire, the epithelial-to-mesenchymal transition dynamics, and phenotypic adaptation in stochastic environments with applications to drug resistance and adaptive therapies. We are located in the Texas Medical Center, close to active clinical collaborations with clinicians at MD Anderson Cancer Center and Baylor College of Medicine.