Created by: Heber Rocha
Issue 157: The computational model recapitulates the patterns of intratumoral hypoxia. Based on data from a hypoxia fate-mapping system, we developed a computational model to investigate the motility and phenotypic persistence of hypoxic and post-hypoxic cells during tumor progression. The results revealed that post-hypoxic cells have an enhanced persistent migratory phenotype that promotes the formation of invasive structures. In this work, the combination of mathematical modeling with experimental data showed great potential to probe the dynamics and suggest hypotheses. (See preprint here).