Created by: Mark Robertson-Tessi, Mehdi Demaghi, Sandy Anderson

Issue 189: Back (and) into the future. This image made the cover of Cancer Research in 2017 and combines in vitro and in silico demonstrations of phenotypic segregation in mixed metabolic phenotype spheroids driven by distinct environmental niches. As predicted by the model the phenotypes separated each into their favorite habitat with high glycolytic phenotypes (red) moving towards the edge, whilst low glycolytic phenotypes occupy the center (green). You can learn more about this work here. Today this image serves as the cover for the upcoming AACR special conference on evolutionary dynamics in carcinogenesis and response to therapy in sunny Tampa, Florida, from March 14-17, 2022. Abstracts are due on January 7th. We look forward to seeing you all there!