202

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Issue 202: This artwork is a representation of our recent manuscript published in Molecular Biology and Evolution illustrating our new base pair resolution in silico genome tool for agent-based modeling, Gattaca. Gattaca is named after the four bases, Adenine, Cytosine, Guanine, and Thymine. The artwork represents this by depicting a Clustal multiple sequence alignment of sequences generated from randomly sampling nucleotides from the tumor suppressor gene, TP53. This gene will almost always be used as a gene of interest in the set of genes that Gattaca would use during simulations. We insert the bases GATTACA at a random site within these generated sequences to ensure sequence identity for this motif prior to alignment. The colors pay homage to sequence alignment visualizers that always use a specific color pattern when visualizing sequence data in a GUI. Although fun to visualize, Gattaca serves as a novel and powerful tool that provides us with the ability to directly compare mechanistic agent-based model genomes with patient sequence data.