Created by: Luis Zapata
Issue 255: We explore the dynamic landscape of tumor evolution through our innovative single-cell stochastic branching model. This cutting-edge simulation captures the intricate interplay between positive and negative immune selection, offering valuable insights into the emergence and fate of phenotypically similar clones. Witness the unfolding of a vibrant ecosystem, represented by distinct colors, where clones expand, compete, and succumb to immune pressures (green cells). This model sheds light on the delicate balance between tumor heterogeneity and the immune system's role in shaping cancer progression, where the final outcomes are antigen-free edited (blue) and antigen-rich escaped (red) clones. Out method can identify these outcomes, providing an invaluable tool for researchers and clinicians seeking to develop novel immunotherapies and personalized treatment strategies.