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Created by: David Morselli

Issue 270: The use of oncolytic viruses as cancer treatment has received considerable attention in recent years, however the spatial dynamics of this viral infection is still poorly understood. We present here a stochastic agent-based model describing infected and uninfected cells for solid tumours, which interact with viruses in the absence of an immune response. Our results show that the presence of spatial constraints in tumours’ microenvironments limiting free expansion has a very significant impact on virotherapy, in particular the variability in outcomes