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Created by: Sharan Poonja, Ana Forero Pinto, and Kasia Rejniak (@RejniakLab)
Issue 279: The extracellular matrix (ECM) architecture is a key stromal component that can either suppress cancer growth or enable cancer invasion. We developed a hybrid agent-based model that handles mechanical interactions between tumor cells and ECM fibril bundles. This model reproduces three distinct tumor-associated collagen signatures (TACS) observed in histology images and simulates dynamic transitions among TACSs. The gif image shows changes in the ECM fibril patterns during a cell colony growth and invasion.