286

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Issue 286: The original concept of metaphenotype was defined in 2017 after observing simulations with similar initial conditions but vastly different outcomes, due to spatial location of phenotypes in context leading to collective actions. The artwork depicts the difficulty in predicting outcomes based on initial condition alone (hence, the jumbled lines). In this recent work, we define metaphenotypes in the context of tumor-immune interactions. A more formal definition of Metaphenotype: A collective phenotype that integrates multiple phenotypes within a specific context. Explicitly accounts for interactions between distinct phenotypes & contexts that together drive specific behaviors eg acid invasion or immune evasion. See tweet thread on the paper, here.