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Issue 299: Many resistance-conferring mutations often carry a substantial fitness cost in the absence of treatment. As a result, we would expect these mutants to undergo purifying selection and be rapidly driven to extinction. In our new paper, we propose that frequency-dependent ecological interactions play a major role in the prevalence of preexisting resistance by ameliorating this resistance cost when the mutant population is small. We combine numerical simulations with robust analytical approximations to provide a rigorous mathematical framework for studying the effects of frequency-dependent ecological interactions on the evolutionary dynamics of preexisting resistance, and we demonstrate the prevalence of positive ecological interaction in a set of common resistant mutants in EGFR+ NSCLC. Our results suggest that frequency-dependent ecological effects can play a crucial role in shaping the evolutionary dynamics of preexisting resistance. Based on the paper: Frequency-Dependent Ecological Interactions Increase the Prevalence, and Shape the Distribution, of Preexisting Drug Resistance published in PRX Life.