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Issue 310: Why are plants and trees largely free from developing cancer? Understanding this distinct property and its evolutionary context requires theoretical models that incorporate the developmental picture, but also the ecological tumor dynamics. In our new paper we discuss how the generalized Lotka-Volterra model, a standard tool to describe species-rich ecological communities, provides a framework to develop our understanding of the ecology of heterogeneous tumors. Based on the paper: Modeling tumors as complex ecosystems published in iScience.