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Issue 330: The cancer-immunity cycle is a classical theoretical framework delineating the dynamic process of antitumor immune responses, comprising seven pivotal steps: (1) tumor antigen release, (2) antigen presentation, (3) T cell activation, (4) T cell trafficking, (5) tumor infiltration, (6) antigen-specific recognition, and (7) tumor cell killing. The sustained operation of this cycle relies on positive regulation at each step, whereas tumors can disrupt it through immunosuppressive microenvironments, ultimately leading to immune escape. In this study, we developed a Quantitative Cancer-Immunity Cycle (QCIC) model to mechanistically characterize tumor-immune interactions. Using advanced colorectal cancer as a paradigm, this model successfully predicted synergistic effects of chemotherapy combined with antiangiogenic agents and disease progression trajectories.