346

---

Click the image below to view the full size version of this cover.

Issue 346: High-grade serous ovarian cancer (HGSOC) remains a challenging disease to treat due to high recurrence rates, acquired resistance, and cumulative toxicity. During the 12th IMO Workshop we explored the development of a multi-strike, extinction protocol for frontline treatment of HGSOC, which aims to eradicate tumors not through a singular magic bullet but through a series of different therapies (strikes). In developing such a protocol there are three key questions: what treatments to give, how long to give it, and when to switch? Illustrated here are how we integrated mathematical modeling and data analysis to address these challenges: i) we devised a method to identify patterns in fluctuating methylation sites to assess hematopoietic toxicity risk from liquid biopsy (colorful lines in the background), ii) we used mathematical cell cycle modeling to design effective low- dose combinations of targeted agents (model diagram in bottom left), and iii) we developed a new mathematical model to analyze the interplay between chemotherapy, gut microbiome toxicity, and immunotherapy, demonstrating how mitigating microbiome damage could enhance immune response (equations in top right). The next iteration of the IMO workshop is now only a month away! To get yourself into the mood, check out reports from previous workshops on the bioRxiv channel.