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Issue 164: Our recent mathematical analyses of incidence patterns suggest that esophageal squamous cell carcinoma (ESCC) is likely associated with a premalignant field that may develop very early in life and is under the influence of strong historic trends, which vary by sex and race. In the image, an organic human form with esophagus stands in front of our Figure illustrating a new functional regularization method for handling period trends, with some randomly generated trajectories for field defect (FD) onset rates. See full publication in PLoS Computational Biology here.