Created by: Saskia Haupt, Alexander Zeilmann
Issue 166: Colorectal cancer usually develops from normal mucosa over precursor lesions to a carcinoma which can be analyzed using a histopathological section (from bottom to top, left part of figure). We developed a mathematical model to describe this process, including multiple pathways of carcinogenesis, with ordinary differential equations and the Kronecker structure (right part of figure). This specific matrix structure is the key to our paper. It allows for detailed mathematical analysis, low computational costs and medical interpretability. To find out more, read our paper or our blog post on the MathOnco Blog, reach out on Twitter, or join our mini-symposium at SMB 2021 (Session 11 and 12).