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Issue 180: Cells undergoing metastasis can acquire both drug resistance and migratory properties. This is a multi-scale process, illustrated here for ER+ breast cancer. On the cell scale, cells transition between different phenotypes in the phenotypic landscape due to noise and the administration of drugs (Left). This defines the cell’s adaptive level of drug resistance and its position along the epithelial-mesenchymal transition axis (EMT). On the population scale, this subsequently manifests in multiple parallel paths to long-term resistance in a given cancer cell population (pre-existing reversibly resistant cells, stochastic switching and dynamic equilibrium, and drug-induced plasticity; Right). To learn more, check out our recent paper here.