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Issue 183: Gene regulatory networks can explain the existence of multiple phenotypes observed in melanoma. Simulated gene expression based on these networks show that the four experimentally identified phenotypes (Melanocytic, Transitory, Neural Crest-like and Undifferentiated) are a result of further classification of the two broader "macro" states that form the proliferative and invasive phenotypes. These four states can further be subdivided into an ensemble of smaller "micro" states (represented within the circles) which possibly contribute to the high degree of heterogeneity seen within melanoma tumors. To find out more, read our paper here.