Created by: Sandy Anderson, Maximilian Strobl, Jeffrey West, Chandler Gatenbee

Issue 204: In our recent paper, we examined the tumor-immune eco-evolutionary dynamics from pre-cancer to carcinoma in colorectal cancer using a combination of computational modeling, ecological analysis of digital pathology data, and neoantigen prediction. The artwork shows artistically arranged quadrat count maps of species abundance on a histology slide which we used to dissect the tumor ecology during tumorigenesis (blue=low; red=high). Our work provides evidence that it is the construction of an immunosuppressive niche by the tumor, rather than PD-L1 overexpression, that is the predominant pathway to overcome immune predation during tumor initiation in colorectal cancer.