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Issue 206: In our recent paper, we employed quantitative MRI to characterize intra- and inter-tumoral heterogeneity in a murine model of HER2+ breast cancer. This artwork pairs our in vivo and ex vivo measurements, showing MRI-derived tumor subregions (i.e., habitats) alongside immunofluorescence images of the same lesion. Using MRI data acquired prior to treatment, we identified whole-tumor phenotypes that exhibited differential response to treatments, suggesting that baseline phenotypes can predict therapy response.