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Created by: Virginia Turati

Issue 216: The key message of our work is that induction chemotherapy in BCP-ALL does not select for genotypes, as it leaves the overall extent of intratumor genetic heterogeneity present in the diagnostic disease unaffected. Instead, it induces canalization (or bottleneck selection) at the level of cell states, which are more heterogeneous than previously appreciated, and partially encoded through aberrant methylation. The idea behind our cover is that a tornado is a metaphor for this biological process of canalization. At the bottom of the image is the tumor cells, heterogeneous in their cell states. As the tornado roams through the tumor with its destructive force, it collects the cells, but some cells, which exist in a resistant cell state, are spared from it. The cover image was entirely computed in R and the code can be found here.