Created by: Andrea Comba, Pedro Lowenstein, Maximilian Strobl

Issue 220: Heterogeneity is a landmark of glioblastoma tumors. How such heterogeneity is set up remains unknown. We recently discovered the existence of “oncostreams”, active multicellular accumulations of elongated and aligned cells which display mesenchymal properties, and migrate throughout the tumor and along invasive borders. Furthermore, “oncostreams” can carry  immune cells such as macrophages and microglia, and their structure and function depends on Collagen I. We believe “oncostreams” are essential to establishing glioblastoma cellular and molecular heterogeneity. To learn more, read our papers here [1, 2, 3].