223

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Click the image below to view the animated version of this cover.

Issue 223: The sum and the parts. This image shows how multiple distinct metastases respond to an adaptive therapy regimen. In our off-lattice, multi-domain, agent-based model, we grow and treat different sets of tumors with variation in the total burden, number of metastases, proliferation rates, drug resistance, cell turnover, heterogeneity, and seeding. We show how a single cycle of adaptive therapy can be used as a tool to infer different traits from tumor dynamics. Read our preprint here.