Created by: Alvaro Ruiz-Martinez, Chang Gong & Aleksander S. Popel

Issue 233: We present a hybrid computational modeling platform, spQSP, to extend quantitative systems pharmacology (QSP) models of immuno-oncology by combining them with spatial agent-based models (ABM). We analyze the region at the edge of the tumor called the Invasive Front (IF) and apply the model to immunotherapy of triple-negative breast cancer. Here we show 3D profiles of CD8+ T cell densities. Central tumor in yellow, IF in red, and normal tissue in green. To learn more, check out the paper here.