243

---

Click the image below to view the full size version of this cover.

Issue 243: The opposite of the word fragile can be defined as antifragile — wherein systems derive a benefit from volatile perturbations. The concept of antifragility has been extensively explored in financial applications as a method of hedging risk of market volatility. These same techniques and principles can be applied to cancer treatment, where volatility due to treatment can be controlled and manipulated by a cancer physician to induce extinction or improve response. The mathematical framework is based on the curvature of dose response functions (concave or convex). The artwork shows some example dose response curves, ranging from high (blue) to low (red) concavity.