MathOnco23 Talks
Conference recordings
Please enjoy all talks from the first MathOnco conference in Phoenix, Arizona held in May 2023!
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Cancer is the uncontrolled growth of abnormal cells in the body, and it develops from a single cell to bigger masses which take control of portions of healthy tissues. Following the Darwinian evolution theory, to successfully ...
Recent advances in understanding the role of somatic evolution have led to a growing field of research aimed at ...
The “Public Goods Problem” has confounded biologists (and social scientists) for generations. In the cancer biology ...
This talk explains the evolution and biology of sex chromosomes, emphasizing how sex chromosome variation and analytical biases affect genomic studies, gene expression, and cancer research, with implications for understanding sex ...
Cancer is an inherently evolutionary disease, characterized by a proliferative phenotype that is often able to ...
Treatment resistance due to tumor heterogeneity is an ongoing problem for maintaining a sustained response to ...
Despite rapid initial responses and low toxicity, targeted therapies commonly fail to provide long-term benefits to ...
Cancer evolution shapes treatment resistance and therapeutic outcomes. By viewing tumors as evolving ecosystems, evolutionary-informed strategies such as adaptive therapy and sequential treatment approaches can exploit tumor ...
The development of cancer from healthy somatic cells is fundamentally an evolutionary process. Understanding this ...
The adenomatous polyposis coli gene (APC) is one of the earliest driver mutations observed in sporadic cancer. ...
The evolution of metastasis represents a lethal and incurable stage of cancer progression. Yet, the evolutionary ...
Adaptive therapy is an approach to controlling therapeutic resistance in cancer that was inspired by integrated ...
Prostate cancer is the fifth-leading cause of cancer-related death in men. Current standard-of-care treatment ...
Growing amounts of patient data has led to the promise of precision medicine for cancer patients. However, most ...
PARP inhibitors (PARPis) have revolutionized ovarian cancer treatment, yet these drugs often fail after a few ...
Adaptive Therapy (AT) is a therapeutic strategy for preventing tumor resistance for as long as possible by ...
Epidemiological studies have demonstrated that aspirin can protect against colorectal carcinogenesis. The mechanisms underlying this, however, are not fully understood. While the molecular mechanisms of aspirin and its ...
Spatial architecture in biological systems, such as human tissues, plays a crucial role in how they evolve and ...
The questions of how healthy colonic crypts homeostatically maintain their size, and how homeostasis is disrupted ...
Many pathogenic cellular populations, including solid tumours, are densely packed. However, little is known about ...
Sex differences in cancer arise from intrinsic biological and evolutionary mechanisms established early in development, shaping tumor growth, treatment response, and clinical outcomes while motivating sex-aware models for ...
Adaptive phenotypes (i.e., driver events) in cancer must confer either a cell-intrinsic (birth minus death) or ...
Identifying cancer progression as soon as feasible is critical for calibrating the patient's treatment and ...
This talk explores cancer as a dynamic tissue ecosystem, emphasizing the critical role of fibroblasts and the tumor microenvironment in regulating tumor growth, therapy response, and resistance. By integrating experimental ...
Recently, the US Food and Drug Administration announced an initiative to reform the decades-old maximum-tolerable ...
Drug combinations are used to treat most types of cancer, and are often essential to treatments with curative ...
The polyploid giant cancer cell (PGCC) state is a common response of cancer cells to various stressors including ...
Accurate prioritization of immunogenic neoantigens is key to developing personalized cancer vaccines and ...
Tumor hypoxia, which arises due to the rapid growth of tumor cells and insufficient vascularization, can create ...
BACKGROUND: It is estimated that over 720,000 people are living with bladder cancer in the United States. Many of ...
Chimeric Antigen Receptor (CAR) T-cell therapy is a type of immunotherapy which involves engineering a patient’s ...
Whole genome doubling (WGD) facilitates rapid tumor evolution and is a hallmark of many cancers, including ...
Colorectal cancer (CRC) shows high incidence and mortality, in part because of the role of the tumor ...
This talk presents mathematical models of tumor evolution in chronic lymphocytic leukemia (CLL) and colorectal cancer, showing how genetic mutations and growth dynamics predict disease progression, treatment need, and cancer ...
Sedimentation is a somewhat unexpected phenomenon in which cancer cells encapsulated in a 3D hydrogel matrix ...
Brain tumor associated edema is a significant cause of patient morbidity and mortality often requiring continual ...
This talk highlights the critical role of sex differences in mathematical oncology, demonstrating how biological sex influences glioblastoma biology, imaging biomarkers, treatment response, and predictive modeling. By integrating ...
High grade gliomas (HGG) are the most frequent, most aggressive, and most heterogeneous of all malignant brain ...
Glioblastoma multiforme (GBM) remains one of the most aggressive and untreatable cancers (median survival ~18 mo.). ...
Tumor relapse during therapies is thought to reflect the ability of tumor cells to escape treatment via ...
Agent-based models can reveal cancer as a complex, evolving ecosystem shaped by interactions between tumor cells, normal tissue, and the microenvironment. Using prostate cancer and lung cancer examples, Sandy Anderson shows how ...
Agent-based models have been used to examine many different aspects of tumor biology, allowing researchers to ...
The phenotypic and genetic variations within tumors are central contributors to tumor heterogeneity and represent a ...
Introduction and Motivation. Neoadjuvant therapy (NAT) is the standard-of-care for patients with locally advanced ...
Recent evidence suggests that nongenetic (epigenetic) mechanisms play an important role at all stages of cancer ...
Intratumor cellular heterogeneity and non-genetic cell plasticity in tumors pose a recently recognized challenge to ...
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