356

---

Click the image below to view the full size version of this cover.

Issue 356: The widespread use of cytotoxic drugs has shaped the paradigm of uniformly administering a ‘maximum tolerated dose’ to patients; however, this approach fails to account for the dynamic and heterogeneous nature of challenging cancers. The cover image illustrates the translational capabilities of mathematical modeling to address these issues, transforming clinical patient information (depicted by the patient scan on the left) into digital avatars (shown by the blue wavy figure on the right) that enable personalized treatments (represented by the drug in the middle of the image). The underlying patient treatment and disease dynamics drive the digital representation, as indicated by the connecting waveforms between the two figures that emerge from the equations and mathematical analysis in the background.