256

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Issue 256: Studying cancer growth in a 3D in-vitro setting provides more realistic conditions than 2D culture growth, as well as increased flexibility of data collection than in-vivo conditions. However, the increased dimensionality makes mathematical modelling more challenging, especially when the model describes a variety of cell states and dynamics. This artwork represents the dual representation of cancer cells in a 3D culture, the continuum and the discrete. Using these two representations in our recent work, we developed an efficient calibration and validation framework for hybrid (discrete-continuum) models of cancer growth.