366

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Issue 366: This artwork represents a dynamic landscape where tumor growth is not predetermined, but rather emerges from the delicate dialogue between tumor cells, immune effector cells, and temperature. Inspired by Figure 5c of the linked paper, the composition transforms a mathematical diagram into a visual metaphor of biological equilibrium: trajectories flowlike currents that converge or disperse depending on the temperature that permeates the system. In the warm (red) region of the main diagram, therapeutic heat acts as a catalyst for order: the green trajectories converge toward a stable point symbolizing tumor control. In the intermediate zone, uncertainty arises, where two possible destinies coexist—control or escape—reflecting the bistability characteristic of complex systems. Finally, in the cold (green) domain of the main diagram, the tumor persists, regardless of the initial conditions. By simultaneously displaying these three states, the piece suggests that hyperthermia is not merely about temperature, but about precision. The appropriate selection of a thermal regimen, adjusted to each patient’s initial conditions (ρ and α), can redirect the system’s trajectory toward control. In this way, the artwork proposes an aesthetic vision of personalized medicine: parameterizing biology to transform the outcome of tumor control.