371

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Created by: Grant Kinsler

Issue 371: A cell’s function is determined by both its ancestry and location within a tissue. New developments in imaging-based spatial transcriptomics now allow us to measure gene expression at high-resolution and precision within a cell’s spatial context but are incompatible with random-barcode-based clone tracing. We developed a new method for clone tracing that’s compatible with these approaches, allowing for high-resolution clone and gene expression measurements in spatial context. The art, somewhat inspired by Andy Warhol, shows the same tumor (top) with clonal information, genes that are driven by spatial patterns, and a gene that is driven by clonal patterns. The bottom panels show a zoomed-in location for the same tumor.