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Issue 215: Glioblastoma is the most common adult brain tumour. Its aggressive nature makes it difficult to treat successfully. In our study, we used an ex vivo tumour model developed from human glioblastoma tissue to evaluate a new treatment modality (oncolytic virus) under clinical investigation. We then used this tumour model to develop a computational model of glioblastoma dynamics that accounts for cellular interactions within the tumour. Our integrated modelling strategy can be applied to suggest mechanisms of therapeutic responses for central nervous system cancers and to facilitate the successful translation of new therapies into the clinic.