Jeffrey West

Group Leader: Evolutionary Dynamics, Interactions, & Therapy @ Moffitt Cancer Center

Tampa, Florida, USA

Twitter: @mathoncbro
Website: https://labpages.moffitt.org/westj/

Keywords (click a keyword to view other similar labs):
antifragility • evolutionary therapy • spatial heterogeneity • Lenia • game theory • cellular automata.

Description: The goal of our research group is to aid in targeting treatment resistance by constructing mathematical models of 1) tumor evolution and heterogeneity and 2) evolutionary-minded treatment strategies, employing techniques such as agent-based modeling, dose response convexity analysis (second-order effects), and evolutionary game theory. These methods are broadly applicable to many cancer types, but recent publications have focused on applications to breast and prostate cancer.

Jeffrey West

Evolutionary Dynamics, Interactions, & Therapy

Jeffrey West M

Group Leader: Evolutionary Dynamics, Interactions, & Therapy @ Moffitt Cancer Center

Tampa, Florida, USA

Blog posts written by Jeffrey West M :

Drug-induced proliferation curves preserve convexity

Behind the paper

Learning Dynamics with Neural Networks

Promising machine learning methods to aid mechanistic modelling

Mechanistic Learning

The best of both worlds.

Games and the Treatment Convexity of Cancer

Behind the Paper

Adaptive Therapy in 2021

Math Modeling: Year in Review

The past 185 weeks in MathOnco

The road to 1000 subscribers

Adaptive dose personalization

What's first, what's second?

HAL + EvoFreq

A tutorial on modeling & visualizing tumor evolution

Space Accelerates Evolution

Realized Darwinian fitness

Talks held by Jeffrey West M :

75 years of Math Onco

"The integration of advanced mathematical and computational methodologies is playing an increasingly central role in cancer research, offering critical insights..."

Artworks by Jeffrey West M :

Issue 364

"This artwork aggregates patient-specific transitions between four immunophenotypic states defined by CD34 and CD38 expression, visualized as an overlaid chord..."

Issue 339

"The artwork is inspired by the concept of antifragility, where a system can benefit from input variation. In the book,..."

Issue 303

"PARP inhibitors have transformed ovarian cancer care, but many patients require dose adjustments or drug holidays due to toxicity. We..."

Issue 295

"This week’s artwork highlights MathOnco, with a call to action! Are you interested in joining our team? Click here to..."

Issue 286

"The original concept of metaphenotype was defined in 2017 after observing simulations with similar initial conditions but vastly different outcomes,..."

Issue 275

"Cancer research has traditionally focused on developing new agents, but an underexplored question is that of the dose and frequency..."

Issue 264

"Quantifying and characterizing metastases is tough due to the dispersal of cancer cells across multiple sites and the paucity of..."

Issue 260

"This week's cover artwork comes from a simulation within the Lenia (from the Latin word lenis, meaning 'smooth') mathematical framework...."

Issue 249

"This artwork was featured on the cover of Trends in Cell Biology, April 2023. Modeling tumor evolution via integrative team..."

Issue 243

"The opposite of the word fragile can be defined as antifragile — wherein systems derive a benefit from volatile perturbations...."

Issue 238

"Glucose is converted to energy through "fermentation" or "oxidation". Generally, if oxygen is available, cells will oxidize glucose to CO2..."

Issue 229

"IsoMaTrix is a software package that aids in the construction, analysis and visualization of three-strategy matrix games (MATLAB). IsoMaTrix.js is..."

Issue 227

"It all began with one of those fateful lunchtime conversations. “Wouldn’t it be cool if the mathonco newsletter had cover..."

Issue 218

"Have you ever wanted to visualize a histogram or density from counts of (x,y) pairs? Say if you wanted take..."

Issue 217

"By enabling us to better map out the spatial distribution of multiple cell types at the same time, emerging multiplexed..."

Issue 208

"Adaptive therapy aims to leverage competition between drug-sensitive and resistant cells by adjusting treatment to maintain the tumor at a..."

Issue 204

"In our recent paper, we examined the tumor-immune eco-evolutionary dynamics from pre-cancer to carcinoma in colorectal cancer using a combination..."

Issue 203

"This artwork is based on a bifurcation diagram that emerged from our paper on the Estrogen paradox that was recently..."

Issue 177

"The size of a cell’s local interaction neighborhood leads to emergent patterns via contact inhibition. Based on our recent preprint,..."

Issue 171

"The letters of the text "This week in MathOnco" provide a chemotactic signal for migrating cells (in white). Cells within..."

Issue 158

"A bird's eye view of a ductal tree network."

Issue 156

"Made in HAL."

Issue 155

"Loosely inspired by the 'evolutionary cycles' featured in the cover image here."

Issue 154

"An example IsoMatrix diagram."

Issue 153

"An example EvoFreq diagram."

Issue 152

"A circular EvoFreq diagram."

Jeffrey West ^M

Blog posts written by Jeffrey West ^M :

Talks held by Jeffrey West ^M :

Artworks by Jeffrey West ^M :